Preservation of platelet function and number by prostacyclin during cardiopulmonary bypass

CONTINUING EDUCATION Coagulation and Platelet Function During Cardiopulmonary Bypass Surgery

Bachmann and coworkers in Chicago have performed a careful study of coagulation parameters after cardiopulmonary bypass surgery .1 In 512 patients, they found a 4% incidence of postoperative bleeding. More than half of these cases were due to surgically correctable causes. About 2% of the population were considered to be bleeding because of an acquired coagulation disorder. One half of these ca...

The platelet function defect of cardiopulmonary bypass.

The use of cardiopulmonary bypass (CPB) during cardiac surgery is associated with a hemostatic defect, the hallmark of which is a markedly prolonged bleeding time. However, the nature of the putative platelet function defect is controversial. In this study, blood was analyzed at 10 time points before, during, and after CPB. We used a whole-blood flow cytometric assay to study platelet surface g...

Platelet function defects related to cardiopulmonary bypass.

Rapid recovery of platelet function after cardiopulmonary bypass.

The complex mechanism of altered platelet function during cardiopulmonary bypass (CPB) is a subject under investigation because it might result in understanding of blood-biomaterial interaction and, subsequently, optimal intervention. However, the common biochemical and functional parameters of platelets do not clarify the mechanism.’ Recently, new apparatuses were constructed to mimic the hemo...

Myocardial Preservation during Hypothermic Cardiopulmonary Bypass: A Team Endeavor

____________ _ Myocardial failure is the primary cause of death following operation using hypothermic cardiopulmonary bypass. The mean mortality rate for coronary bypass in Medicare patients in the United States for 1984 was 5.5%.1njury to the heart is caused by aortic cross-clamping or total circulatory arrest. The lesion of hypoxia is characterized by progressive acidosis. The severity of aci...